Abstract
<jats:p><jats:bold>Objective</jats:bold>: performing a comparative analysis of various indicators of mental and behavioral disorders in the population living in the Lugansk region over a long period of time, followed by the development of scientifically based recommendations. <jats:bold>Materials and methods</jats:bold>: the research was carried out in the Luhansk region for the period 2004–2023. The total time interval of 20 years is divided into two equal ten-year periods: peacetime (2004–2013) and wartime (2014–2023). The work used official data from the annual reports of the statistical department of the Luhansk Clinical Neuropsychiatric Hospital of the LPR and data from the Lugansk Coordination Center for Health Protection “Indicators of public health and activities of medical organizations of the Luhansk region”, “Indicators of public health and activities of medical organizations of the Luhansk People’s Republic” for 2004–2023. <jats:bold>Results</jats:bold>: when comparing the peacetime and wartime periods, a statistically significant deterioration in all indicators characterizing mental health during wartime was proved. <jats:bold>Conclusions</jats:bold>: the depressive wartime environment in the Luhansk People’s Republic is a significant risk factor for the occurrence or exacerbation of mental disorders, an increase in the duration of inpatient treatment of patients with mental and behavioral disorders, a deterioration in the clinical prognosis of the disease and, as a result, disability</jats:p>