Abstract
<jats:p>Nephrotic syndrome (NS) in children is a common kidney disorder often associated with immune and endocrine imbalance. Thyroid hormone changes may affect NS pathogenesis, clinical manifestations, and treatment response. Objective. To assess the role of thyroid dysfunction in the clinical course of NS in children. Methods. Eighty children (1–18 years) with NS and 30 healthy controls were studied. According to serum TSH, T3, and T4, patients were divided into groups with normal thyroid function, hypothyroidism, and hyperthyroidism. Clinical, biochemical, ultrasound, and immunological parameters were evaluated. Results. Subclinical hypothyroidism was common in active NS. In hypothyroid patients, edema lasted longer, hypoproteinemia, hypercholesterolemia, and proteinuria were more severe (p0,05), with frequent relapses and corticosteroid dependence. Conclusion. Thyroid dysfunction increases NS severity. Regular thyroid evaluation and endocrinologist involvement are crucial in pediatric management. </jats:p>