Abstract
<jats:p>INTRODUCTION. Despite the fact that more 120 years have passed since the first mention of Marchiafava-Bignami disease, the issues of etiology, pathogenesis, MRI and treatment of this disease are still not fully resolved. However mortality rate remains high. AIM. To present a clinical case of a patient with Marchiafava-Bignami disease and discuss issues of diagnosis and treatment of this and other clinical variants of alcohol-induced damage to the nervous system. СASE PRESENTATION. The case report of 51-year-old woman with Marchiafava-Bignami disease and typical neurological and imaging findings linked to alcohol abuse is presented. She was comorbid hypertension and diabetes mellitus. Are being discussed pathology, pathogenesis, clinical, MRI and therapy. СONCLUSION. In this case the illness started with a convulsive seizure after alcohol abuse. Then cognitive impairment began to increase. Typical neurological and MRA findings were discovered. Comorbid hypertension and diabetes mellitus ware aggravated the progression. After four months the woman was died at home. No autopsy was performed. KEYWORDS: Marchiafava-Bignami disease, MRI, therapy</jats:p>