Abstract
<jats:p>The article presents conceptual provisions reflecting the transformative potential and transformation possibilities of using the spatial-network policy of regional development from the standpoint of scientific and methodological foundations of spatial and network economics. It is shown that the most effective among the instrumental means of implementing regional structural and economic transformations is the deconcentration approach to the placement of productive forces, infrastructure loci and settlement zones for the population. In the context of developing the scientific foundations of network structuring of economic space, the article formulates directions, principles and mechanisms for implementation, the justification of which was carried out taking into account the dominant trends of urbanization and agglomeration in the domestic mesoeconomic space. It is argued that the networking of economic space will help reduce agglomeration pressure in urbanized spaces. For this purpose, it is proposed to use programs and projects for the infrastructuring of the so-called development corridors that connect the nodes of spatial and economic networks. The article may be useful to researchers of regional economic problems, as well as specialists dealing with issues of applied management of the development of regional socio-economic systems.</jats:p>