Abstract
<jats:p> Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathies are common among people of Duhok city in northern Iraq. The study was carried out to determine the prevalence of G6PD deficiency among individuals with thalassemia and sickle cell disorder, Glucose 6 phosphate dehydrogenase was estimated in eighty-four (84) persons with hemoglobinopathies to observe its prevalence. A manual procedure was used to estimate the G6PD enzyme activity of fresh samples from the participants using BIOLABO SA, G6PD assay kit (Maizy, France).G6PD deficit was detected in 15(17.90%) of the case, (10.71%) of SCD, and (7.14%) of beta thalassemia syndromes with a statistically significant association between G6PD enzyme level and clinical diagnosis. No significant correlation between RBC count and RDW was seen between low and G6PD enzyme level individuals with hemoglobinopathies.The study emphasized the prevalence of G6PD deficit to be higher among individuals with hemoglobinopathy compared to the normal subject from a previous study from the same geographical region.</jats:p>