Abstract
<jats:p>This chapter delves into the fascinating intersection of folk medicine and modern pharmacology, focusing on plant-based remedies used in traditional healing practices for tackling multiple diseases. It highlights the importance of ecochemical interface studies, exploring how factors like climate, soil, and pollution affect the effectiveness of medicinal plants. By combining traditional knowledge with contemporary scientific approaches, the chapter uncovers the full potential of plant compounds for multitarget disease treatments. Topics covered include phytochemical profiling, pharmacodynamics, and how environmental stress impacts plant chemistry. Through real-life case studies, we see how specific plants have proven therapeutic effects, underscoring the value of cross-disciplinary collaboration and ethical sourcing. The chapter concludes by calling for future research that bridges eco-centric drug discovery with personalized medicine, leveraging innovative tools such as AI and systems biology to fully realize the therapeutic promise of natural compounds.</jats:p>