Abstract
<jats:p>The integration of artificial intelligence (AI) models with synthetic biology offers transformative potential for enhancing plant epigenetic regulation. Plant epigenetics, involving modifications such as DNA methylation, histone modifications, and non-coding RNAs, plays a crucial role in regulating gene expression, development, and stress responses.. This chapter explores how AI can optimize the design, prediction, and real-time manipulation of plant epigenetic mechanisms, accelerating advancements in crop improvement. Furthermore, synthetic biology techniques, such as gene editing and the creation of synthetic gene circuits, can be precisely targeted using AI models to improve plant resilience and productivity. The integration of AI with synthetic biology in plant epigenetic regulation holds significant promise for addressing global agricultural challenges, enhancing food security, and fostering sustainable farming practices.</jats:p>