Abstract
<jats:p>Tobacco cessation interventions delivered by dental professionals have shown significant promise in addressing one of the most prevalent preventable health risks. This multi-centre randomised controlled trial evaluated the effectiveness of integrating artificial intelligence-based risk-stratification tools into tobacco cessation counselling in dental clinic settings. Between January 2023 and March 2025, 584 adult tobacco users were recruited from 12 dental clinics and randomly assigned to receive either standard tobacco cessation counseling (control group, n = 292) or AI-enhanced counseling incorporating personalized risk assessment and tailored intervention strategies (intervention group, n = 292). The primary outcome was biochemically validated tobacco abstinence at 6-month follow-up. Secondary outcomes included patient engagement metrics, counsellor satisfaction scores, and accuracy of relapse risk prediction.</jats:p>