Abstract
<jats:p>Immunological aspects of relations in parasite-host systems «cestodes-fishes», both on cellular and molecular levels, were under investigation. A comprehensive study of morphofunctional and biochemical aspects of the adaptation of cestode plerocercoids to the effects of the immune system of their hosts – fish has been started by our team. The micromorphological and biochemical characteristics of plerocercoid reactions in response to the effects of the host blood serum were analyzed. The regulatory role of the substances prostaglandin E2, serotonin and GABA identified in the body of plerocercoids in relation to the immune system of fish has been established. The assembly and annotation of transcriptomes of three types of cestodes, as well as organs of the immune system of fish - intermediate hosts of cestodes, were performed. The anti-inflammatory and wound healing potential of excretory-secretory products and extracts from plerocercoids was assessed.</jats:p>