Abstract
<jats:p>Aim. To present a clinical case illustrating a staged successful surgical treatment of atherosclerotic cardiovascular pathology, identified during preoperative colorectal cancer screening, within the framework of a comprehensive cardio-oncological assessment. To emphasize the importance of personalized management of patients with various diseases and interdisciplinary collaboration. Key points. Cardiometabolic diseases and colorectal cancer represent significant medical, socio-economic, and public health challenges, occupying leading positions in mortality statistics worldwide. In recent years, the scientific community has increasingly focused on investigating gut microbiota dysbiosis, which contributes to the development and progression of various chronic conditions. Inflammation, immune response dysregulation, disturbances in lipid and carbohydrate metabolism, arterial hypertension, and genetic mutations are primary risk factors for the development and progression of atherosclerosis and colorectal cancer in patients over 60 years of age. Conclusion. Continued research is essential to identify novel biological markers and therapeutic targets aimed at establishing effective clinical strategies for risk stratification and secondary prevention of cardiovascular and oncological diseases.</jats:p>