Abstract
<jats:p>Thrombotic microangiopathy (TMA) is a syndrome characterized by endothelial injury and thrombotic occlusion of the microvasculature of kidneys and other organs. Clinical manifestations of TMA include microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. Dysregulated complement system activation plays a key role in the pathogenesis of TMA that can be primary (due to the pathogenic variants of the complement genes) or secondary. The latter can be induced by various causes, including drugs, autoimmune diseases, infections, transplantation of hemopoetic cells and solid organs, etc. We report a case of complementmediated TMA successfully treated with eculizumab in patient with HCV-associated cryoglobulinemic vasculitis.</jats:p>