Abstract
<jats:p>The review was based on analysis of 180 sources from databases PubMed, eLibrary, Cohrane Library, MEDLINE for 2015–2025 using keywords precision medicine, personalized medicine, neuro-oncology, oncology, cranio-cerebral injury, neuro-trauma, neuro-proteomics and AI. The purpose of the study was to demonstrate, on the basis of analysis of publications on precision medicine application in neurosurgery, the significance and perspectives of mentioned approach in modern neurosurgical practice. The methods of precision medicine, digital revolution and progress in multi-modal Big Data processing permit to better understand of tumor genesis, their clinical heterogeneity, functional effects and causes underlying their resistance to treatment. The precision medicine methods provide valuable information on pathophysiological mechanisms underlying neuro-trauma through analysis of complex protein interactions and changes. The future of precision medicine in neurosurgical practice is in permanent enhancement of AI and machine learning, permitting rapid and accurate decision-making based on comprehensive molecular data. The future of neurosurgery lies in harmonious integration of such interdisciplinary approaches as precision medicine and clinical neurosurgery to discover new possibilities of targeted and personalized therapy.</jats:p>