Abstract
<jats:p>In Ukraine, cases of inhalation poisoning with sewage gases are observed every year among municipal workers and residents of private households, unfortunately, most of them are fatal. The aim. Based on published data and our own research, to investigate the clinical and pathohistological features of lung damage in acute poisoning with sewage gases. Materials and methods. The medical data of a male patient who died as a result of poisoning with sewage gases were analyzed. The preparations were examined using an Olympus CX 41 microscope in transmitted light, at a magnification of 100, 200 and 400 times. Results. The clinical picture of inhalation poisoning with a mixture of toxic gases in a 46-year-old man was accompanied by pronounced neurotoxic and pulmonary toxic effects. Rapid loss of consciousness and development of purulent-necrotic changes in the lung tissue indicated high concentrations of toxic gases. According to the results of pathohistological studies, the following were found in the lung tissue: foci of hemosiderosis, acute alveolar emphysema and dysatelectasis. In the myocardium: moderately pronounced arteriosclerosis, arterial spasm, foci of stromal edema, abnormal arrangement of muscle fibers, fragmentation and hypoxic dystrophy, interstitial sclerosis with perifocal hypertrophy of cardiomyocytes, perivascular sclerosis and lipomatosis. In the brain tissue: edema-swelling with few perivascular hemorrhages. Uneven, sometimes increased, blood filling of the studied organs with signs of impaired rheological properties of the blood was noted. Conclusions. The toxicity of sewage gases is due to the simultaneous action of chemicals and highly pathogenic flora contained in the gas mixture. Clinical signs of damage are rapid loss of consciousness and rapid development of purulent-necrotic changes in the lung tissue, namely: purulent-fibrous bronchopneumonia with intraalveolar hemorrhages, with foci of hemosiderosis, acute alveolar emphysema and dysatelectasis.</jats:p>