Abstract
<jats:p>Amphibian skin-derived peptides represent a remarkable class of bioactive molecules with broad therapeutic and biological potential. This book provides a comprehensive overview of their historical discovery, evolution, and clinical implications, highlighting how these peptides have inspired new approaches in wound treatment, antimicrobial therapies, and immunomodulation. The biological properties of these peptides, including antimicrobial, antioxidant, and immunomodulatory activities, are explored in detail, with emphasis on their unique origin and structural diversity. In addition, the cellular mechanisms activated following peptide exposure are analyzed, illustrating the molecular pathways through which these molecules influence cell proliferation, migration, inflammation, and tissue repair. Special attention is given to the actions of these peptides in the skin, where they demonstrate potent effects on tissue regeneration, oxidative stress reduction, and immune modulation. By integrating historical, mechanistic, and applied perspectives, this book serves as an essential resource for researchers, clinicians, and students interested in the therapeutic potential of amphibian skin peptides.</jats:p>