Abstract
<jats:p>Background. Atrial fibrillation (AF), one of the most prevalent cardiac arrhythmias, has a substantial global morbidity and mortality rate. According to recent research, the pathophysiology of AF may be significantly influenced by changes in the lipid profile, macrominerals, and trace elements. In order to shed light on any potential correlations and clarify them, this study compared the levels of lipid profile parameters, magnesium (Mg), calcium (Ca), specific trace elements and some other markers in serum of patients with AF compared to healthy individuals. Materials and methods. The measured markers include lipid profile (cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL)), macrominerals Mg, Ca and some trace elements — copper (Cu), chromium (Cr), selenium (Se), zinc (Zn), iron (Fe). The above markers were measured in 100 AF patients (50 males, 50 females) and 100 supposedly healthy subjects (50 males, 50 females). Results. Statistical data analysis revealed a significant elevation in serum levels of Cu and a decrease in Cr, Se, Zn, Fe, Mg, with non-significant differences in Ca in patients as compared to the control group and for both sexes. The study revealed a significant elevation in Cu levels in females versus males (P ≤ 0.05) and a significant decrease in Fe levels in females compared to males (P ≤ 0.05). In contrast, there was a significant elevation in the levels of cholesterol, TG, LDL-C and VLDL-C and a decrease in HDL-С in serum of patients with AF as compared to the control group for both sexes. Conclusions. There was no effect of sex on the studied markers except Fe, Cu.</jats:p>