Synthesis of 5-[4ʹ-(phenoxydimethylenoxy)-phenyl]-10,15,20-tris(N-methylpyridinium- 3ʹ-yl)porphyrin Triiodide and the Study of its Interaction with Representative Oligonucleotides poly[d(AT)2] and poly[d(GC)₂]

<jats:sec> <jats:title/> <jats:p>Porphyrins and their analogues, due to their unique physicochemical properties, have a wide range of applications. Synthetic tetraarylporphyrins with an asymmetric substituent system are of particular interest. In this regard, an asymmetric porphyrin was synthesized, containing a phenyl fragment on the periphery of the porphyrin macrocycle. Subsequent quaternization of the compound with methyl iodide was carried out in order to obtain water-soluble porphyrin. Its structure was confirmed by &lt;sup&gt;1&lt;/sup&gt;H NMR spectroscopy and MALDI-TOF spectrometry. The photochemical properties and structural features of the complexation of synthesized porphyrin with representative oligonucleotides poly[d(AT)&lt;sub&gt;2&lt;/sub&gt;] and poly[d(GC)&lt;sub&gt;2&lt;/sub&gt;] have been studied. According to the results obtained, the studied compound forms a highly stable complex with poly[d(GC)&lt;sub&gt;2&lt;/sub&gt;] by the intercalation mechanism. In the case of poly[d(AT)&lt;sub&gt;2&lt;/sub&gt;], porphyrin binds in the minor groove.</jats:p> </jats:sec>