Abstract
<title>Abstract</title> <p>Background Complex vascular anomalies (CVA) involve multiple tissue types across large anatomic regions, making characterization with conventional MRI challenging and time intensive. Whole-body (WB) or limited WB-MRI may enable more efficient assessment. Objective To retrospectively evaluate an abbreviated WB-MRI protocol using Ferumoxytol for comprehensive characterization of CVA. Methods Clinical, imaging and management information from patients undergoing Ferumoxytol-enhanced WB-MRI (July 2020-May 2025) was retrospectively reviewed following IRB approval. In the development phase, sequences tested included 3D-RAVE, 3D-VIBE, axial SSFSE T2, and 3D-T2-SPACE. Scan duration, technical image quality, and clinical grading of reporting elements for CVA were assessed by 2 radiologists. An abbreviated protocol was implemented using 3D-VIBE or RAVE, and axial SSFSE T2, with an optional time-resolved MRA using gadolinium contrast for high-flow lesions. Descriptive statistics and 2-tailed t-tests were utilized for analysis. Results Protocol development phase included 32 patients (15M,17F) median age 11.8y (0.2–52.4), and scan duration 57 min (17–134). Implementation phase involved 45 patients (17M, 28F) median age 10.6y (0.01–42.3), and scan duration 32 min (9–77). Average number of stations were RAVE (2.4), VIBE (4.3), SSFSE (3.6) and 3DT2 (2.6). Average technical image quality score was 4.3/5. Mean clinical grade of reporting elements was 4.6/5. Additional TWIST sequence was used in 5 patients to assess suspected high-flow component. All studies were diagnostic, with 3D VIBE/RAVE and SSFSE T2 mandatory for assessment. After multidisciplinary discussion, management decisions were altered in 57% of cases. Conclusions We demonstrate feasibility of an abbreviated WB MRI protocol using Ferumoxytol contrast for CVA.</p>