Abstract
<ns7:p>Background Peri-implantitis is a progressive inflammatory disease affecting tissues around dental implants, often leading to bone loss and implant failure. Bibliometric analysis, which applies quantitative methods to scientific publications, provides a macro-level view of research growth, key contributors, and evolving themes, offering insights to guide clinical applications. Methods This bibliometric analysis examined publications on regenerative therapies for peri-implantitis over the past 30 years published in Scopus. Main parameters included publication output by decade, journal impact, keyword occurrences, highly cited articles, and geographic distribution of research outputs. The data will be filtered, divided and analyzed using VOSviewer to create keywords maps and perform bibliometric distribution analysis. Results A total of 186 articles were identified with a sharp rise in publications observed over time: 5.9% (1995–2005), 21.0% (2006–2015), and 73.1% (2016–2025), reflecting rapid research development in recent years. The United States was the top contributor (33 publications), followed by Germany (24) and Italy (20). Leading journals included Clinical Oral Implants Research and Journal of Clinical Periodontology. Keyword evolution showed a transition from basic biological concepts to advanced clinical methods and randomized controlled trials. Collaboration networks also expanded across countries, particularly in Europe and North America. Discussion The rapid growth in publications underscores escalating clinical and academic interest. Concentration of impactful research in select countries and journals reflects established expertise but also signals the need for broader international collaboration. Thematic prevalence suggests the field is progressing toward refining biomaterials and surgical protocols. Conclusions Over the past three decades, research on regenerative therapy for peri-implantitis has grown substantially in both scale and scope. This study demonstrated how the field has shifted from basic science to clinical applications, identifying leading contributors, and offering insights to guide future investigations and improve therapeutic strategies.</ns7:p>