Figure 2 from Febuxostat Enhances the Antitumor Efficacy of 2-Fluoroadenine and 5′-Methylthioadenosine in <i>MTAP</i>-Deleted Cancer

<jats:p>&lt;p&gt;Nucleotide concentrations. &lt;b&gt;A,&lt;/b&gt; Mono-, di-, and trinucleotide levels in isogenic &lt;i&gt;MTAP&lt;/i&gt;+ and &lt;i&gt;MTAP&lt;/i&gt;− HT1080 cells treated with nothing (NT), 2 μmol/L 2FA alone, or with 10 μmol/L MTA. Length of time of treatment was either 8 or 24 hours. Black bars show adenine nucleotides, whereas red bars show 2FA nucleotides. The percentage of 2FA relative to adenine for each nucleotide is shown above the red bars. &lt;b&gt;B,&lt;/b&gt; Nucleotide levels from HT1080 &lt;i&gt;MTAP&lt;/i&gt;+ and &lt;i&gt;MTAP&lt;/i&gt;− tumors (&lt;i&gt;n&lt;/i&gt; = 3) grown in SCID mice treated with either 2FA alone or 2FA + MTA. Error bars show SEM.&lt;/p&gt;</jats:p>