Abstract
<jats:title>Abstract</jats:title> <jats:p>This chapter discusses the final years of the pandemic. Cholera came back again in 1834 like a set of pincers, with one thrusting up the Mississippi and the other coming across the Atlantic. This third wave revisited some locations in the Trans-Appalachian West and found some previously unscathed towns that experienced devastating mortality. Outbreaks also occurred along the Eastern Seaboard, with the Savannah Valley suffering the worst. The fourth wave in 1835 was confined to the nation’s midsection and showed lessening intensity but demonstrated the disease’s destructive powers in newly visited places. Charleston, South Carolina, was the scene of the pandemic’s final assault in the summer of 1836. The experience of Thomas Grimké and his family exemplified how cholera’s terrors affected a broad cross-section of the nation’s population.</jats:p>