Abstract
<jats:p>Synthetic biology has garnered widespread attention for its scientific merit and applicative value. It is regarded as a new paradigm in life science research (“build to learn”), and a core driving force for the iterative advancement of biotechnology and the transformative development of biomanufacturing (“build to use”). The techno-economic core thread of “Synthetic Biology – Biotechnology – Biomanufacturing – Bioeconomy is striking a new chord of the times for the common development of humanity. Synthetic Biology Roadmap 2030 is the outcome of in-depth collaborative research by numerous scholars. Drawing fully upon relevant international roadmaps and strategic development reports, and integrating the latest advances in the field, it proposes for the first time a four-in-one disciplinary architecture for synthetic biology encompassing “theoretical connotations, enabling technologies, application prospects, and governance principles”, while rationally forecasting the development goals and implementation pathways to 2030. As China’s contribution to the global landscape of synthetic biology roadmaps, this work will serve as a vital reference for research, education, technology transfer, public engagement, and public literacy in the field of synthetic biology. Furthermore, we hope it will provide decision-making support for national scientific research planning and deployment, disciplinary development and industrial growth of synthetic biology, empowering it to fuel new quality productive forces in biomanufacturing.</jats:p>